Hydrogels are widely used in biomedical area of research. Hydrogels are usually used in fabrication of contact lenses, hygiene products, biosensors, wound dressings, and tissue engineering applications. The polymer 2-hydroxyethyl methacrylate (HEMA) based hydrogel synthesis and their use in textiles industry was also reviewed. Poly-Hema is a soft, flexible, water absorbing plastic used in making soft contact lenses. HEMA is a clear liquid compound obtained by reacting methacrylic acid with ethylene oxide or propylene oxide. HEMA and polymer hydrogel filler are used for soft tissue reconstruction by facile polymerization. The synthesis of random copolymer including HEMA through free radical polymerization is also reviewed. Polymeric fillers are widely used as an alternative for breast reconstruction materials. This review focuses on recent advancements in several types of biomedical hydrogels including conductive hydrogels, injectable, responsive, nanocomposite hydrogels, etc. Thermo responsive hydrogels use temperature as external stimulus to show sol-gel transition and they can form hydrogel around the body temperature. Textile based transdermal therapy is currently being applied using drug loaded thermoresponsive hydrogel. Hydrogels made by natural and synthetic polymers for textile based transdermal treatments are mentioned.